-
Journal of Clinical Microbiology Mar 2021
Topics: Bordetella; Bordetella Infections; Humans; Urinary Tract Infections
PubMed: 33441397
DOI: 10.1128/JCM.02748-20 -
Emerging Infectious Diseases Dec 2015We report 2 cases of pulmonary Bordetella hinzii infection in immunodeficient patients. One of these rare cases demonstrated the potential transmission of the bacteria...
We report 2 cases of pulmonary Bordetella hinzii infection in immunodeficient patients. One of these rare cases demonstrated the potential transmission of the bacteria from an avian reservoir through occupational exposure and its persistence in humans. We establish bacteriologic management of these infections and suggest therapeutic options if needed.
Topics: Adult; Aged; Animals; Bordetella Infections; Humans; Immunocompromised Host; Lung Diseases; Male; Opportunistic Infections; Poultry; Respiratory Tract Infections
PubMed: 26584467
DOI: 10.3201/eid2112.150400 -
Journal of Clinical Microbiology Apr 1996Over a 3-year period, an adult cystic fibrosis patient underwent eight episodes of pulmonary exacerbation of his disease. At least one of two different strains of... (Review)
Review
Over a 3-year period, an adult cystic fibrosis patient underwent eight episodes of pulmonary exacerbation of his disease. At least one of two different strains of Bordetella hinzii could be isolated from sputum samples in every instance. The differentiation of B. hinzii from related taxa and its role as an etiologic agent of infections are discussed. The two isolates of B. hinzii reported are the third and fourth human-derived strains described in the literature.
Topics: Adult; Bordetella; Bordetella Infections; Cystic Fibrosis; Humans; Lung Diseases; Male; Middle Aged; Opportunistic Infections; Species Specificity; Sputum
PubMed: 8815118
DOI: 10.1128/jcm.34.4.966-969.1996 -
European Journal of Biochemistry Jul 2000The structure of the core-lipid A region of the lipopolysaccharides from Bordetella hinzii and Bordetella bronchiseptica has been analyzed. Lipopolysaccharides were...
The structure of the core-lipid A region of the lipopolysaccharides from Bordetella hinzii and Bordetella bronchiseptica has been analyzed. Lipopolysaccharides were deacylated using strong alkaline hydrolysis, the products were separated by high performance anion-exchange chromatography and analyzed by NMR and mass spectrometry. The following structure of the products can be deduced from the experimental results: where for the product from Bordetella hinzii N = H, R = H, beta-FucN4N- or partially N-acetylated Sug-(1-3)-beta-FucN4N and for the product from Bordetella bronchiseptica N = alpha-Hep, R = H, beta-FucN4N, beta-FucN4NMe or partially N-acetylated Sug-(1-3)-beta-FucN4N or Sug-(1-3)-beta-FucN4NMe; Sug = 2,3-diamino-2,3, 4-trideoxy-hex-4-enuronopyranosyl.
Topics: Bordetella; Bordetella bronchiseptica; Carbohydrate Sequence; Hydrolysis; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Oligosaccharides
PubMed: 10880983
DOI: 10.1046/j.1432-1327.2000.01512.x -
Revista Espanola de Quimioterapia :... Jun 2022
Topics: Bordetella; Bordetella Infections; COVID-19; Humans; Pneumonia; SARS-CoV-2
PubMed: 35247945
DOI: 10.37201/req/160.2021 -
Emerging Infectious Diseases Sep 2021A patient in Virginia, USA, who had previously undergone multiple kidney transplantations showed signs of Bordetella hinzii bacteremia and meningitis. This emerging...
A patient in Virginia, USA, who had previously undergone multiple kidney transplantations showed signs of Bordetella hinzii bacteremia and meningitis. This emerging pathogen has been increasingly identified as a clinically significant pathogen in immunosuppressed and, less frequently, immunocompetent patients. This patient was treated and recovered without further issue.
Topics: Bordetella; Humans; Kidney Transplantation; Meningitis; Virginia
PubMed: 34424178
DOI: 10.3201/eid2709.210350 -
International Journal of Molecular... Apr 2024, a Gram-negative bacillus commonly associated with respiratory infections in animals, has garnered attention for its sporadic cases in humans, particularly in...
, a Gram-negative bacillus commonly associated with respiratory infections in animals, has garnered attention for its sporadic cases in humans, particularly in immunocompromised individuals. Despite its opportunistic nature, there remains limited understanding regarding its pathogenicity, diagnostic challenges, and optimal treatment strategies, especially in the context of immunosuppression. Herein, we present the first documented case of acute bronchitis caused by in an immunocompromised patient following double-lung transplantation. The patient, a former smoker with sarcoidosis stage IV, underwent transplant surgery and subsequently developed a febrile episode, leading to the identification of in broncho-alveolar lavage samples. Antimicrobial susceptibility testing revealed resistance to multiple antibiotics, necessitating tailored treatment adjustments. Our case underscores the importance of heightened awareness among clinicians regarding infections and the imperative for further research to elucidate its epidemiology and optimal management strategies, particularly in immunocompromised populations.
Topics: Lung Transplantation; Humans; Bordetella; Bordetella Infections; Immunocompromised Host; Male; Middle Aged; Anti-Bacterial Agents; Transplant Recipients
PubMed: 38731927
DOI: 10.3390/ijms25094708 -
Emerging Infectious Diseases Mar 2013
Topics: Animals; Bordetella; Bordetella Infections; Cambodia; Carrier State; Disease Reservoirs; Laos; Rats; Thailand; Zoonoses
PubMed: 23750354
DOI: 10.3201/eid1903.120987 -
Nature Communications Jul 2021Zoonotic transfer of animal pathogens to human hosts can generate novel agents, but the genetic events following such host jumps are not well studied. Here we...
Zoonotic transfer of animal pathogens to human hosts can generate novel agents, but the genetic events following such host jumps are not well studied. Here we characterize the mechanisms driving adaptive evolution of the emerging zoonotic pathogen Bordetella hinzii in a patient with interleukin-12 receptor β1 deficiency. Genomic sequencing of 24 B. hinzii isolates cultured from blood and stool over 45 months revealed a clonal lineage that had undergone extensive within-host genetic and phenotypic diversification. Twenty of 24 isolates shared an E9G substitution in the DNA polymerase III ε-subunit active site, resulting in a proofreading deficiency. Within this proofreading-deficient clade, multiple lineages with mutations in DNA repair genes and altered mutational spectra emerged and dominated clinical cultures for more than 12 months. Multiple enzymes of the tricarboxylic acid cycle and gluconeogenesis pathways were repeatedly mutated, suggesting rapid metabolic adaptation to the human environment. Furthermore, an excess of G:C > T:A transversions suggested that oxidative stress shaped genetic diversification during adaptation. We propose that inactivation of DNA proofreading activity in combination with prolonged, but sub-lethal, oxidative attack resulting from the underlying host immunodeficiency facilitated rapid genomic adaptation. These findings suggest a fundamental role for host immune phenotype in shaping pathogen evolution following zoonotic infection.
Topics: Adaptation, Physiological; Animals; Bacterial Proteins; Bacterial Zoonoses; Bordetella; DNA Polymerase III; Evolution, Molecular; Host-Pathogen Interactions; Humans; Immunocompromised Host; Mutation; Phylogeny; Poultry; Receptors, Interleukin-12
PubMed: 34301946
DOI: 10.1038/s41467-021-24668-7 -
Genome Announcements Aug 2015Bordetella hinzii is primarily recovered from poultry but can also colonize mammalian hosts and immunocompromised humans. Here, we report the first complete genome...
Bordetella hinzii is primarily recovered from poultry but can also colonize mammalian hosts and immunocompromised humans. Here, we report the first complete genome sequences of B. hinzii in two isolates recovered from humans. The availability of these sequences will hopefully aid in identifying host-specific determinants variably present within this species.
PubMed: 26316634
DOI: 10.1128/genomeA.00965-15